Endocrine Abstracts

Physiological and molecular examinations provided evidence for the receptor-mediated influence of the pineal hormone melatonin on insulin secretion of pancreatic β-cells. The predominant effect is a reduction the rate of insulin secretion transmitted by downregulation of intracellular cAMP concentrations. In addition, there is also evidence for an activation of the PLC-IP3-pathway. Further investigations established the existence of the melatonin-receptor MT1, ...

There is a well documented link between melatonin and insulin. Morphological, molecular and functional investigations have shown that the pineal hormone melatonin (MT) influences the insulin secretion. The effects were mediated by specific, high-affinity, pertussis-toxin-sensitive, G-protein-coupled MT1- as well as MT2-membrane receptors which were detected in pancreatic tissue and islets of rats and humans and additionally in rat insulinoma cells INS1. Using the Gi-protein-ad...